Monoclonal antibodies are produced using hybridoma technology. This technology was invented by George Kohler and Cesar Milstein in 1975 to enable large-scale production. In this process, a short-lived antibody-secreting B plasma cell is fused with an immortal myeloma cell using Polyethylene Glycol (PEG) to form a hybridoma. These hybridoma cells possess the ability to grow indefinitely (from the myeloma cell) and produce specific antibodies (from the B plasma cell).