Question 15 of 28intermediate💡 UnderstandMCQ1 mark

Assertion: In hybridoma technology, B cells are fused with myeloma cells. Reason: Myeloma cells are immortal.

Exercise: EXERCISES | Q: 16
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Explanation

Option (A) is correct. According to the textbook context, both statements are true, and the reason correctly explains the assertion. The context clearly states that in hybridoma technology, 'the short-lived antibody secreting normal plasma cell is fused with immortal myeloma cells.' The myeloma cells are described as 'immortal,' and the resulting hybridoma cells 'acquire immortal growth, a typical attribute of a myeloma cell.' The fundamental purpose of this fusion is precisely because B cells have 'a definite life span and die after that,' making them unsuitable for long-term culture. By fusing B cells with immortal myeloma cells, scientists create hybridoma cells that combine the antibody production capability of B cells with the immortal growth property of myeloma cells. Thus, the immortality of myeloma cells is the key reason why they are selected for fusion with B cells in this technology.