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Molecular Detective: Blotting & Selection Lab

Gene Cloning

Step into the CCMB Hyderabad Molecular Diagnostics Unit to master blue-white selection and blotting techniques. Learn how scientists identify recombinant colonies and detect specific DNA, RNA, and proteins through interactive visualizations.

25 min
Duration
3
Missions
11
Problems
160
XP

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📖 Your Story

You are a research intern at the Centre for Cellular and Molecular Biology (CCMB), Hyderabad, one of India's premier research institutes. Your mentor Dr. Padma has assigned you to the diagnostics wing where you'll learn the critical techniques of selecting recombinant bacteria and identifying biomolecules using blotting methods.

What You'll Learn

  • Understand the principle of blue-white selection using lacZ gene and X-gal substrate
  • Differentiate between Southern, Northern, and Western blotting techniques
  • Identify appropriate detection methods (probes, antibodies) for each blotting type
  • Apply knowledge to select the correct technique for specific molecular detection scenarios

How to Play

1Observe the blue-white selection simulation carefully to understand how lacZ gene inactivation creates white colonies
2Interact with the blotting technique visualizations to see how DNA, RNA, and proteins are transferred and detected
3Answer questions about each technique based on what you observe in the visualizations
4Complete all three missions to earn your Molecular Diagnostics certification

3 Missions Await

1

Colony Screening Challenge

4 problems · 40 XP

2

Blotting Technique Explorer

4 problems · 60 XP

3

Diagnostic Applications Master

3 problems · 60 XP

Molecular Detective: Blotting & Selection Lab — Class 12 Bio Technology Lab | Apar Academy